SUBMIT MANUSCRIPT

Donnish Journal of Biomedical Research

July 2016 Vol. 3(1), pp. 001-005

ISSN: 2984-8954

Copyright 2016 Donnish Journals




Original Research Paper


Serum levels of Arginase Isoenzyme Activity, Alpha-Fetoprotein-L3 and Endostatin as Biomarkers for Hepatocellular Carcinoma in Egyptian Patients


Azza Faried1*, Lamiaa Mobarak1, Khadiga K. El Gohary2, Hala H. El-Deeb3, Said El-Feky4, Abeer Ahmed Abdelmonem5, Nashwa Ahmed Zaki6 and Ayman Abdel-Hady Alkhalegy7

1Tropical Medicine Department, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
2Biochemistry Department, El Sahel Teaching Hospital, Egypt.
3Clinical Pathology Department, El Sahel Teaching Hospital, Egypt.
4Biochemistry Department, Damanhur National Medical Institute, Egypt.
5Microbiology and Immunology, Beni-Suef faculty of medicine.
6Clinical pathology, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
7Department of General Surgery, Al Sahel Teaching Hospital, Cairo, Egypt.

Corresponding Author: Azza Faried

Accepted 24th June, 2016.



Abstract


Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. It commonly develops on cirrhotic livers, and surveillance programs have therefore been suggested to identify early HCC, at a stage when it remains suitable for surgical therapy and has a better clinical outcome. The biomarkers alpha-fetoprotein (AFP)-L3, arginase and endostatin can be measured in the routine clinical setting, it may be useful or useless for hepatocellular carcinoma. Aim: The current study introduced a new serum tumor biomarker levels in HCC detection and investigate their benefit as predictors and follow-up of liver cancer. Methods: This study was conducted on a total number of 110 participants admitted to Hepatology and Gastroenterology Department in NHTMRI (National Hepatology & Tropical Medicine Research Institute). The participants of this study were divided into three groups as follows; Group I: 30 cases LCD, Group II 30 patients LC group and Group III as HCC individuals, in addition to 20 healthy subjects (as controls). Results: The obtained increasing specificity of AFP, the AFP-L3 can be used as a measure of cancerous changes in the HCC. The high specificity of arginase (85%) and endostatin (84%) can reflect the usefulness of these markers in HCC follow-up especially endostatin which has a marked sensitivity (90%) in HCC cases under this study. Conclusion: These results demonstrate the beneficial role of Endostatin as it is considered superior to other markers such as AFP, (AFP)-L3, arginase in the diagnosis of HCC.

Keywords: Alpha-fetoprotein-L3, Arginase, Endostatin and Hepatocellular carcinoma.

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Cite This Article:

Azza Faried, Lamiaa Mobarak, Khadiga K. El Gohary, Hala H. El-Deeb, Said El-Feky, Abeer Ahmed Abdelmonem, Nashwa Ahmed Zaki and Ayman Abdel-Hady Alkhalegy. Serum levels of Arginase Isoenzyme Activity, Alpha-Fetoprotein-L3 and Endostatin as Biomarkers for Hepatocellular Carcinoma in Egyptian Patients. Donnish Journal of Biomedical Research 3(1) 2016 pp. 001-005.


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