Donnish Journal of Infectious Diseases and Immunity

October 2016 Vol. 2(3), pp. 011-015

Copyright 2016 Donnish Journals

Original Research Paper

Study of Anti-Tuberculosis Drug Resistant Pattern among the Tuberculosis Patients Visiting German Nepal Tuberculosis Project

Simkhada RC,1 Shah Y,2,3* Thapa J,3 Adhikari N,2 Paudyal R,1 Khadka KS,1 Dahal B,1 Chhetri A,1 Amatya J,1 Maharjan B3,4 and Shrestha B4

1Kathmandu College of Science and Technology, Kathmandu, Nepal.
2Everest International Clinic and Research Center, Kathmandu, Nepal.
3Division of Bioresources, Hokkaido University Research Center for Zoonosis Control, Hokkaido, Japan.
4German Nepal Tuberculosis Project (GENETUP), National Reference Laboratory, Kalimati, Kathmandu, Nepal.

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Accepted 16th September, 2016.


Tuberculosis (TB) is a major public health problem in Nepal. Multidrug-resistant (MDR) strains are serious threats to the control of TB and comprise an increasing public health problem. The aim of this study was to determine the anti-tuberculosis drug resistance pattern among TB patients visiting German Nepal Tuberculosis Project (GENETUP) by using proportion method. The descriptive cross-sectional study was carried from November 2010 to June 2011. During the study period, 112 pulmonary tuberculosis (PTB) patients attending GENETUP were included in the study. Of a total of 112 culture positive isolates, 96 were from re-treatment cases and 16 were from new cases. Among the culture positive cases, the highest number of culture positive cases belonged to the age group of 21-30 years (36.7%) followed by 11-20 years (14.3%). Out of total tested cases, the patients sensitive to all four drugs were found to be 37.5 % (n=42). The patients that showed resistance to only one drug was found to be 3.6% (n=4) and resistance to two drugs 26.8% (n=30). Similarly, resistance to three drugs was found to be 22.4 % (n=25) and resistance to all four drugs was 9.9 % (n=11) among both cases. Regular monitoring of acquired MDR-TB patients and revising anti-tuberculosis treatment policy should be made at the national level representative for controlling tuberculosis. This method can be used for the early diagnosis and control of MDR-TB in developing countries including Nepal.

Keywords: Multi-drug resistant, Tuberculosis, GENETUP, Nepal.

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Cite This Article:

Simkhada RC, Shah Y, Thapa J, Adhikari N, Paudyal R, Khadka KS, Dahal B, Chhetri A, Amatya J, Maharjan B and Shrestha B. Study of Anti-Tuberculosis Drug Resistant Pattern among the Tuberculosis Patients Visiting German Nepal Tuberculosis Project. Donnish Journal of Infectious Diseases and Immunity 2(3) 2016 pp. 011-015.

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