SUBMIT MANUSCRIPT

Donnish Journal of Microbiology and Biotechnology Research

December 2014 Vol. 1(2), pp. 023-034

Copyright 2014 Donnish Journals




Original Research Paper


Evaluation of Serum Levels of Pro-inflammatory Cytokines (interleukins 2, 6, 8) in Fertile and Infertile Men


Ihsan Edan Abdulkareem Alsaimary

Department of Microbiology, College of Medicine, University of Basrah, Iraq.

Corresponding Author E-mail: ihsanalsaimary@gmail.com

Accepted 25th November, 2014.



Abstract


The concentration of interleukin (IL) -2, IL-6 and IL-8 were determined in human sera from fertile and infertile males with various types of infertility; Azoospermia, Oligozoospermia, Asthenozoospermia and Teratozoospermia in AL-Najaf AL-Ashraf governorate during March 2013 to August 2013. Oligozoospermia was predominant in the age group 19-29yrs (48)men, while azoospermia recorded the lowest number (6) men in group >40 yrs. Oligozoospermia had the highest record number of 117 men (36%) followed by asthenozoospermia 97 men (30%), teratozoospermia 73 men (22%) and azoospermia 41 men (12%) with statistical differences between various types of infertility P<0.05. The mean level of concentration of interleukin -2 elevated in serum of infertile men reached159.63 pg/ml in comparison with fertile men (control) which reached 24.35 pg/ml. The mean of concentration of interleukin -6 elevated in the serum of infertile men reached 328.75 pg/ml in comparison with fertile men which reached 116.24 pg/ml. The mean level of concentration of interleukin -8 elevated in the serum of infertile men reached 575.68 pg/ml in comparison with fertile men which reached 141.51 pg/ml. The means of interleukins concentration among various types of infertility of infertile men and control (fertile men) were evaluated in the present study. High differences were found among the interleukin concentrations, the various types of infertility P<0.001 and the concentration of interleukin in control the group P<0.01.

Keywords: Cytokines, interleukins, fertile, infertile men.

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Cite This Article:

Ihsan Edan Abdulkareem Alsaimary. Evaluation of Serum Levels of Pro-inflammatory Cytokines (interleukins 2, 6, 8) in Fertile and Infertile Men. Donnish Journal of Microbiology and Biotechnology Research 1(2) 2014 pp. 023-034.


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