SUBMIT MANUSCRIPT

Donnish Journal of Microbiology and Biotechnology Research

December 2014 Vol. 1(2), pp. 018-022

Copyright 2014 Donnish Journals




Original Research Paper


Current Concepts in the Immunological Diagnosis of H. pylori in Basrah Pediatric Oncology Unit


Amer Naes Amer1, Janan G. Hassan1, Ihsan E. Al-Saimary2*

1Department of Pediatrics, College of Medicine, University of Basrah, Iraq.
2Department of Microbiolody, College of Medicine, University of Basrah, Iraq.

Corresponding Author E-mail: ihsanalsaimary@gmail.com

Accepted 25th November, 2014.



Abstract


Objective: The concentration of Immunological markers (IgG, IgM, IgA, C3 and C4 ) were determined for children with cancer in Basrah Pediatric Oncology Unit during 2009. Methods: A prospective comparative case-control study was carried out over 7 months from 12th of March 2009 to 26th of September 2009, the study included 29 children (20 male and 9 female) with different types of malignancies. Investigations were done for H.pylori and one step diagnostic test (which detect the antigen for H. pylori) and determine the concentration of (IgG, IgM, IgA, C3, C4). Results: There is statistically significant higher percentage of patient group having H.pylori comparing to control group with P < 0.05. Regarding H.pylori in relation to immunological status of studied patients, there was a significant association between H.pylori and high IgG with a mean (715.01) for H.pylori positive patient and mean (553.20) for H.pylori negative patient, P< 0.05 which is statistically significant, this was the same regarding IgA when there was a significant association between H.pylori and high IgA with a mean (94.29) for H.pylori positive patient and mean (58.54) for H.pylori negative patient P< 0.05 which is statistically significant, also the same regarding C4 , there was a significant association between H.pylori and low C4 with a mean (47.31) for H.pylori positive patient and mean (79.57) for H.pylori negative patient and P< 0.05 which is statistically significant. Conclusion: This study shows evidence of strong relationships between frequency of H.pylori and immunocompromised children according to immunological investigation.

Keywords: H. pylori, immunology, cancer, children.

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Cite This Article:

Amer Naes Amer, Janan G. Hassan, Ihsan E. Al-Saimary. Current Concepts in the Immunological Diagnosis of H. pylori in Basrah Pediatric Oncology Unit. Donnish Journal of Microbiology and Biotechnology Research 1(2) 2014 pp. 018-022.


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