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Donnish Journal of Medicine and Medical Sciences

May 2015 Vol. 2(4), pp. 052-055

Copyright 2015 Donnish Journals




Original Research Paper


The Role of Nitric Oxide in Vaso-occlusive Crisis in Sickle Cell Disease Patients in Ghana


1C. Antwi-Boasiako*, 1E. Frimpong, 2G. K. Ababio, 2D. Bartholomew, 3A. D. Campbell, 4B. Gyan and 1D. A. Antwi

1Department of Physiology, School of Biomedical and allied Health Sciences, University of Ghana, Ghana.
2Department of Medical Biochemistry, School of Biomedical and allied Health Sciences, University of Ghana, Ghana.
3Department of Pediatric Hematology/Oncology, University of Michigan Hospitals, Ann Arbor, Michigan.
4Departments of Immunology, Noguchi Memorial Institute of Medical Research, University of Ghana, Ghana.

Corresponding Author E-mail: antwiboasiako@chs.edu.gh

Accepted 13th April, 2015.



Abstract


Background: Recent clinical and experimental data suggest that nitric oxide (NO) may play a role in the pathogenesis and therapy of sickle cell disease (SCD) by maintaining the normal vasomotor tone. However, limited data exist in Ghana and it is therefore imperative that data is collated in that regard. Aim and objectives: To determine the levels of NO in HbSS and HbSC patients in steady state, in VOC, and in the immediate post-crisis period. Materials and method: A cross-sectional study was done on 111 SCD patients at steady state, 112 SCD patients in VOC and 67 SCD patients at the immediate post crisis period, all aged 15 to 65 years, with a laboratory diagnosis of SCD at the Sickle Cell Clinic of the Korle-Bu Teaching Hospital with age -matched 102 healthy controls (HbAA) blood donors recruited from the Center for Clinical Genetics and Accra Area Blood Centre at the Korle-Bu Teaching Hospital, Accra. Results: The mean NO value of (8.66 0.75μm) in control subjects were not significantly different from the mean level of (7.62 0.06μm) in steady state (P>0.05). During VOC however, there was a significant reduction in mean NO levels to (2.08 0.81μm) (P<0.05). Mean NO levels rose significantly to (11.97 1.68μm) (P<0.05) in the immediate post crisis period. Conclusion: Nitric oxide levels were diminished during VOC and rebound significantly during the immediate post crisis period in SCD patients

Keywords: Sickle cell disease, Nitric oxide, Vaso-occlusive crisis.

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Cite This Article:

C. Antwi-Boasiako, E. Frimpong, G. K. Ababio, D. Bartholomew, A. D. Campbell, B. Gyan and D. A. Antwi. The Role of Nitric Oxide in Vaso-occlusive Crisis in Sickle Cell Disease Patients in Ghana. Donnish Journal of Medicine and Medical Sciences 2(4) 2015 pp. 052-055.


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