Donnish Journal of Infectious Diseases and Immunity

October 2016 Vol. 2(3), pp. 011-015

Copyright © 2016 Donnish Journals

Original Research Paper

Study of Anti-Tuberculosis Drug Resistant Pattern among the Tuberculosis Patients Visiting German Nepal Tuberculosis Project

Simkhada RC,¹ Shah Y,^2,3* Thapa J,³ Adhikari N,² Paudyal R,¹ Khadka KS,¹ Dahal B,¹ Chhetri A,¹ Amatya J,¹ Maharjan B^3,4 and Shrestha B⁴

¹Kathmandu College of Science and Technology, Kathmandu, Nepal.
²Everest International Clinic and Research Center, Kathmandu, Nepal.
³Division of Bioresources, Hokkaido University Research Center for Zoonosis Control, Hokkaido, Japan.
⁴German Nepal Tuberculosis Project (GENETUP), National Reference Laboratory, Kalimati, Kathmandu, Nepal.

Corresponding Author's Email: yogendra.90@gmail.com

Accepted 16th September, 2016.

Abstract

---

Tuberculosis (TB) is a major public health problem in Nepal. Multidrug-resistant (MDR) strains are serious threats to the control of TB and comprise an increasing public health problem. The aim of this study was to determine the anti-tuberculosis drug resistance pattern among TB patients visiting German Nepal Tuberculosis Project (GENETUP) by using proportion method. The descriptive cross-sectional study was carried from November 2010 to June 2011. During the study period, 112 pulmonary tuberculosis (PTB) patients attending GENETUP were included in the study. Of a total of 112 culture positive isolates, 96 were from re-treatment cases and 16 were from new cases. Among the culture positive cases, the highest number of culture positive cases belonged to the age group of 21-30 years (36.7%) followed by 11-20 years (14.3%). Out of total tested cases, the patients sensitive to all four drugs were found to be 37.5 % (n=42). The patients that showed resistance to only one drug was found to be 3.6% (n=4) and resistance to two drugs 26.8% (n=30). Similarly, resistance to three drugs was found to be 22.4 % (n=25) and resistance to all four drugs was 9.9 % (n=11) among both cases. Regular monitoring of acquired MDR-TB patients and revising anti-tuberculosis treatment policy should be made at the national level representative for controlling tuberculosis. This method can be used for the early diagnosis and control of MDR-TB in developing countries including Nepal.

Keywords: Multi-drug resistant, Tuberculosis, GENETUP, Nepal.

Read: [Full Text - PDF]

Cite This Article:

Simkhada RC, Shah Y, Thapa J, Adhikari N, Paudyal R, Khadka KS, Dahal B, Chhetri A, Amatya J, Maharjan B and Shrestha B. Study of Anti-Tuberculosis Drug Resistant Pattern among the Tuberculosis Patients Visiting German Nepal Tuberculosis Project. Donnish Journal of Infectious Diseases and Immunity 2(3) 2016 pp. 011-015.