Donnish Journal of Microbiology and Biotechnology Research
January 2018 Vol. 5(1), pp. 001-005
Copyright (c) 2018 Donnish Journals
Original Research Paper
Human Beta Defensins-3 Gene Expression in Epithelial Cell and Neutrophils for Children with Leukemia before and after Treatment
Hanan S. Makii1, Awatif H. Issa2* and Abdullah H. Al Saadoon2
1Basra Children Specialty Hospital, Basra Province, Iraq
2Biology Department, College of Science, University of Basrah, Basra, Iraq.
Corresponding Author's Email: awatifhi@gmail.com
Accepted 24th December, 2017.
Abstract
Human Β-defensin-3 (HΒD-3) is the most interesting member of the antimicrobial peptide family. It has abroad spectrum of antimicrobial peptide activity against bacterial, fungal and some viral infections. HΒD-3 gene expression was detected in about 60 specimens from 15 patients before and after chemotherapy for each neutrophil and epithelial cell used for the study of HΒD-3 gene expression. Control samples were 5 patients without chemotherapy suffering from different diseases such as oropharyngitis, tonsillitis, esophagitis and other inflammations. Acute Lymphoblastic Leukemia (ALL) was the most prevalent among patients with leukemia. HΒD-3 expression in epithelial cell (buccal mucosa) and neutrophils before chemotherapy and after chemotherapy (induction phase) was determined.
Keywords: HΒD-3 expression, Molecular identification, Oral cavity, Leukemia patients.
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Cite This Article:
Hanan S. Makii, Awatif H. Issa and Abdullah H. Al Saadoon. Human Beta Defensins-3 Gene Expression in Epithelial Cell and Neutrophils for Children with Leukemia before and after Treatment. Donnish Journal of Microbiology and Biotechnology Research 5(1) 2018 pp. 001-005.
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