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Donnish Journal of Pharmacy and Pharmacology

February 2015 Vol. 1(1), pp. 001-007

Copyright 2015 Donnish Journals




Original Research Article


Evaluation of the Toxic Effect of Ethanolic Extract of Saffron in Male Mice after Subchronic Exposure


Falah Muosa*, Kadhim AL-Rekabi, Salma Jameel Askar and Eman Hashim Yousif

College of Veterinary Medicine, University Of Baghdad, Baghdad, Iraq

Corresponding Author E-mail: senatorlife2011@yahoo.com

Accepted 11th February, 2015.



Abstract


This study is conducted to investigate the toxicity of saffron (Crocous Sativa L) in male Balb-C mice. The range finding study revealed that ethanolic extract of saffron is practically not acutely toxic. The subchronic exposure of mice to two different doses 4000, 5000 mg/Kg.BW orally for five weeks exhibited a significant decrease in WBC, RBC count and low hemoglobin level. Kidney function impairment was observed through a significant increase in serum level of BUN and creatinine, which was more significant after high dose (5000 mg) exposure, histopathological changes like degeneration of epithelial cells, lining the proximal and distal convoluted tubules was also observed. Some liver injury enzyme tests ALT and AST revealed a significant increase in serum activity of AST only after exposure to both doses of plant extract, mild histopathological changes in liver tissue included dilation of the central vein and vacuolar degeneration were observed. There was a significant decrease in body weight of mice proportional to the dose and period of exposure during the time of study.

Keywords: Toxic effect, Ethanolic extract, Saffron, Male mice, Subchronic.

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Cite This Article:

Falah Muosa, Kadhim AL-Rekabi, Salma Jameel Askar and Eman Hashim Yousif. Evaluation of the Toxic Effect of Ethanolic Extract of Saffron in Male Mice after Subchronic Exposure. Donnish Journal of Pharmacy and Pharmacology 1(1) 2015 pp. 001-007.


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